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Seb Larsson returns to the starting XI after missing the games against Crystal Palace and Stoke due to suspension, the Swede replaces Jack Rodwell. In the only other change, Danny Graham makes a rare start as he replaces Will Buckley.
Adam Johnson is named amongst the substitutes after missing out last week.
Sunderland (4-3-3): Costel Pantilimon; Billy Jones, John O'Shea, Sebastian Coates, Patrick van Aanholt; Seb Larsson, Lee Cattermole, Jordi Gomez; Jermain Defoe, Danny Graham, Connor Wickham.
Subs: Vito Mannone, Anthony Reveillere, Santiago Vergini, Liam Bridcutt, Jack Rodwell, Adam Johnson, Will Buckley.
Southampton also make two changes with Victor Wanyama and Shane Long replacing Morgan Schneiderlin and Steven Davis.
Southampton: Kelvin Davis; Nathanial Clyne, Jose Fonte, Maya Yoshida, Ryan Bertrand; Victor Wanyama, Toby Alderweireld; James Ward-Prowse, Sadio Mane, Shane Long; Graziano Pelle.
Subs: Paulo Gazzaniga, Florin Gardos, Steven Davis, Filip Djuricic, Eljero Elia, Harrison Reed, Matt Targett.