Sunderland made two changes from the team that secured a 2-0 home win over Burnley at the weekend, with Gus Poyet opting to bring in Emanuele Giaccherini for Seb Larsson and Ricky Alvarez for Adam Johnson, who misses out after undergoing minor surgery on a thumb injury.
Poyet was only able to name six substitutes with Jack Rodwell, Seb Larsson and Will Buckley all missing.
Sunderland (4-3-3): Vito Mannone; Anthony Reveillere, Santiago Vergini, John O'Shea, Patrick van Aanholt; Emanuele Giaccherini, Liam Bridcutt, Jordi Gomez; Ricky Alvarez, Jermain Defoe, Connor Wickham.
Subs: Costel Pantilimon, Wes Brown, Sebastian Coates, Liam Agnew, Steven Fletcher, Danny Graham.
Kit Symons makes three changes from the first game at the Stadium of Light, with Alexander Kacanikilic, Ross McCormack and Hugo Rodallega all starting and they replace Lasse Vigen Christensen, Moussa Dembele and Bryan Ruiz.
Fulham (4-1-2-1-2): Marcus Bettineli; Jack Grimmer, Shaun Hutchinson, Nikolay Bodurov, Kostas Stafylidis; Ryan Tunnicliffe; Seko Fofana, Alexander Kacaniklic; Ross McCormack; Cauley Woodrow, Hugo Rodallega.
Subs: Gabor Kiraly, Elsad Zverotic, Dan Burn, Lasse Vigen Christensen, Patrick Roberts, George Williams, Moussa Dembélé.