Gus Poyet makes three changes from the 2-1 reverse at Tottenham, with Vito Mannone, Sebastian Coates and Liam Bridcutt replacing Costel Pantilimon, Wes Brown and Adam Johnson.
Jermain Defoe retains his place up front and makes his home debut as Poyet sticks with the 3-5-2 formation he introduced against Spurs.
Sunderland (3-5-2): Vito Mannone; Santiago Vergini, John O'Shea, Sebastian Coates; Billy Jones, Seb Larsson, Liam Bridcutt, Jack Rodwell, Patrick van Aanholt; Steven Fletcher, Jermain Defoe.
Subs: Costel Pantilimon, Jordi Gomez, Ricky Alvarez, Emanuele Giaccherini, Will Buckley, Danny Graham, Connor Wickham.
Fulham make four changes from their 3-2 home win over Nottingham Forest in midweek, as Kit Symons replaces the front three, with Bryan Ruiz, Cauley Woodrow and Moussa Dembele replacing Alexander Kacaniklic, Hugo Rodallega and Ross McCormack.
Scott Parker also misses out after picking up an injury against Forest and he is replaced by Danish u21 international Lasse Vigen Christensen.
Fulham (4-1-2-1): Marcus Bettineli; Jack Grimmer, Shaun Hutchinson, Nikolay Bodurov, Kostas Stafylidis; Ryan Tunnicliffe; Seko Fofana, Lasse Vigen Christensen; Bryan Ruiz; Cauley Woodrow, Moussa Dembele.
Subs: Gabor Kiraly, Elsad Zverotic, Dan Burn, Patrick Roberts, Alexander Kacaniklic, Hugo Rodallega, Ross McCormack.