Santiago Vergini comes in at right back, allowing Wes Brown to switch back to his more familiar central position where he renews his partnership with ex-Manchester United defender John O'Shea.
Will Buckley makes his full debut in place of Adam Johnson who is ruled out through illness but Sunderland are otherwise unchanged from the team who drew 2-2 at West Brom last week.
Billy Jones is on the bench for the first time after recovering from a slight hamstring injury.
Sunderland (4-3-3): Mannone; Vergini, O'Shea, Brown, van Aanholt; Larsson, Cattermole, Rodwell; Buckley, Fletcher, Wickham.
Subs: Pantilimon, Roberge, Jones, Bridcutt, Gomez, Mavrias, Altidore.
Ander Herrera and Jesse Lingard miss out through injury for Manchester United but they are boosted by the return of Robin Van Persie who replaces Javier Hernandez up front.
Manchester United (3-4-1-2): De Gea; Jones, Smalling, Blackett; Valencia, Fletcher, Cleverley, Young; Mata; Rooney, van Persie.
Subs: Amos, Keane, James, Kagawa, Januzaj, Hernandez, Welbeck.