Sunderland boss Paolo Di Canio has named Keiren Westwood the starting choice in goal over his own summer acquisition, Vito Mannone. The pair have battled all summer for the spot and it's the Irishman who has come out with the gloves.
In front of him will be two Premier League debutants in Valentin Roberge who partners captain John O'Shea, while Ondrej Celustka also starts at right-back with Craig Gardner suspended.
In midfield Cabral makes a debut as does Emanuele Giaccherini, with Seb Larsson and Adam Johnson making up the numbers.
Amidst rumours of an impending arrival in Doha to sign for Qatari club El Jaish, Stephane Sessegnon starts in attack alongside Jozy Altidore.
Sunderland (4-4-2): Keiren Westwood; Ondrej Celustka, Valentin Roberge, John O'Shea, Jack Colback; Adam Johnson, Cabral, Seb Larsson, Emanuele Giaccherini; Stephane Sessegnon, Jozy Altidore
Substitutes: Vito Mannone, Ji Dong-Won, Carlos Cuellar, Elh-Hadji Ba, Modibo Diakite, David Moberg Karlsson, Connor Wickham
Meanwhile Fulham gaffer Martin Jol has left new signing and this afternoon's boo-boy Darren Bent on the bench after he signed on loan from Aston Villa yesterday.
Kieran Richardson starts in defence, while debuts are handed to Maarten Stekelenburg, Derek Boateng and Adel Taarabt.
Dimitar Berbatov will lead the line on his own for the Cottagers.
Fulham (4-2-3-1): Maarten Stekelenberg; Sascha Reither, Brede Hangeland, Aaron Hughes, Kieran Richardson; Steve Sidwell, Derek Boateng; Adel Taarabt, Damien Duff, Patjim Kasami; Dimitar Berbatov
Substitutes: David Stockdale, Philippe Senderos, Bryan Ruiz, Giorgios Karagounis, Matthew Briggs, Hugo Rodallega, Darren Bent