Gus Poyet has, as he has hinted all week, made wholesale changes to the Sunderland team that lost at Hull. Only skipper John O'Shea and Fabio Borini retain their places in the squad, with Oscar Ustari coming in in goal, Santiago Vergini replacing the suspended Wes Brown and Liam Bridcutt rested for Lee Cattermole. Andreas Dossena, Emanuele Giaccherini, Seb Larsson and Craig Gardner also come in.
Most interestingly, there's a debut for Argentinian striker Ignacio Scocco, who plays through the middle in place of Jozy Altidore.
Sunderland (4-1-4-1): Oscar Ustari; Ondrej Ceulstka, Santiago Vergini, John O'Shea, Andrea Dossena; Lee Cattermole; Emanuele Giaccherini, Seb Larsson, Craig Gardner, Fabio Borini; Ignacio Scocco
Substitutes: Vito Mannone, Valentin Roberge, Marcos Alonso, Ki Sung-Yeung, Jack Colback, Charis Mavrias, Connor Wickham
Southampton are also coming back off a game against Hull, and Mauricio Pochettino has made six changes to the team that won on Humberside. Former Sunderland goalkeeper Kelvin Davis comes in for Artur Brouc, while Jos Hooiveld, Nathaniel Clyne, Victor Wanyama, James Ward-Prowse and Guly De Prado replace Jose Fonte, Callum Chambers, Jack Cork, Morgan Schneiderlin and Jay Rodriguez.
Southampton (4-2-3-1): Kelvin Davis; Nathaniel Clyne, Maya Yoshida, Jos Hooiveld, Luke Shaw; Steven Davis, Victor Wanyama; James Ward-Prowse, Guly do Prado, Adam Lallana; Rickie Lambert
Substitutes: Paulo Gazzaniga, Jose Fonte, Callum Chambers, Morgan Schneiderlin, Jack Cork, Sam McQueen, Jay Rodriguez