Set for the week commencing 28 October, Mauricio Pochettino's men will make the long journey north to the Stadium of Light, with a place in the quarter-finals of the competition up for grabs.
Southampton booked their place in the final 16 last night courtesy of a 2-0 home victory over Bristol City. The scoreline failed to tell the story though as a much-weakened side struggled to finish off their League One opposition. The win was only sealed seven minutes from time by defender Jos Hooiveld's header.
Sunderland last met the Saints just over a month ago, of course, conceding a late equaliser following Emanuele Giaccherini's early headed goal. The tie will come straight after the weekend's Wear-Tyne derby, ensuring an important week for whomever happens to be in the Stadium of Light dugout this time next month.
Full Capital One Cup Fourth Round Draw
Sunderland v Southampton
Leicester City v Fulham
Burnley v West Ham United