Sunderland boss Paolo Di Canio is taking the cup seriously and makes only a few changes from the site which drew against Southampton at the weekend. Perhaps the biggest news though comes on the bench where Steven Fletcher returns, and Charis Mavrias also sits hoping for a run out.
Vito Mannone starts, while Valentin Roberge comes in for Modibo Diakite to partner John O'Shea. Jack colback has recovered from a mild knock to start at left back.
In midfield there's three changes as Cabral returns alongside David Vaughan and David Moberg-Karlsson makes a start.
Stephane Sessegnon misses out on a starting berth as Ji Dong-Won gets a chance to show what he can do alongside Jozy Altidore in attack.
Sunderland (4-4-2): Vito Mannone; Ondrej Celustka, John O'Shea, Valentin Roberge, Jack Colback; Adam Johnson, David Vaughan, Cabral, David Moberg-Karlsson; Ji Dong-Won, Jozy Altidore
Substitutes: Keiren Westwood, Seb Larsson, Steven Fletcher, Connor Wickham, El-Hadji Ba, Carlos Cuellar, Charis Mavrias.
Meanwhile Karl Robinson goes with a youthful lineup, including 17-year old Dele Alli in central midfield, and loan signings Samir Carruthers and Patrick Bamford also in the side.
On the bench there's also 16-year old Giorgio Rasulo and another teenager in Brendon Galloway.
Former Newcastle crock Alan Smith also makes a start for the Dons, and provides the most experience in the side.
MK Dons (3-5-2): Ian McLoughlin; Anthony Kay, Ben Reeves, Shaun Williams; Dele Alli, George Baldock, Samir Carruthers, Alan Smith, Stephen Gleeson; Izale McLeod, Patrick Bamford
Substitutes: Charlie Burns, Lee Hodson, Jon Otsemobor, Luke Chadwick, Giorgio Rasulo Jason Banton, Brendon Galloway.